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Publish Date:07.March 2016     Visted: Times       

Hao-Hua Huo

Publish Date:01.February 2020     Visted: Times       

Professor of Chemistry
E-mail:
hhuo@xmu.edu.cn
Address: Department of Chemistry,
College of Chemistry and Chemical Engineering,
Xiamen University, Xiamen, 361005, China

Web Site: https://hhuo.xmu.edu.cn/

Education:

  • 2012-2016 Ph.D. in Organic Chemistry, Philipps-Universit?t Marburg, Germany Advisor: Prof. Eric Meggers

  • 2009-2012 M.S. in Organic Chemistry, Xiamen University, China Advisor: Prof. Pei-Qiang Huang

  • 2005-2009 B.S. in Chemistry, Xiamen University, China 

Professional Experience:

  • 2019-present Professor in Department of Chemistry, Xiamen University, China

  • 2016-2019 Postdoctoral Fellow, California Institute of Technology, USA Advisor: Prof. Gregory C. Fu 

Honors and Awards:

  • 2019 Thousand Youth Talents Plan, China

  • 2017 Resnick Postdoctoral Fellowship in Sustainability Science, Caltech

  • 2016 Ph.D. Degree with Highest Honors, Philipps-Universitat Marburg

  • 2011 Xin-Zhan-Wang School Anniversary Scholarship, Xiamen University

  • 2008 National Scholarship, Xiamen University  

Research Interests:
We are interested in using green and sustainable energy to promote chemical reactions, and aim to develop new approaches for efficient and economical synthesis of pharmaceutical molecules. Currently we are focusing on visible-light-induced photoredox transition-metal catalysis.

Selected Recent Publications:

  1. J. Xu, Z. Li, Y. Xu, X. Shu, H. Huo*, Stereodivergent Synthesis of Both Z- and E-Alkenes by Photoinduced, Ni-Catalyzed Enantioselective C(sp3)–H Alkenylation. ACS Catal. 2021, 11, 13567-13574.

  2.  L. Huan, X. Shu, W. Zu, D. Zhong, H. Huo*, “Asymmetric benzylic C(sp3)–H Acylation via dual nickel and photoredox catalysis”, Nat. Commun. 2021, 12, 3536. (featured in Nature Communications Editors’ Highlights, X.S. and L.H. contributed equally.)

  3.  X. Shu, L. Huan, Q. Huang, H. Huo*, “Direct Enantioselective C(sp3)–H Acylation for the Synthesis of α-Amino Ketones”, J. Am. Chem. Soc. 2020, 142, 19058-19064. (Highlighted in Synfacts 2021,17, 0040; Organic Chemistry Portal; D. F. Taber, Org. Chem. Highlights 2021, July 12.; X.S. and L.H. contributed equally.)

  4.  H. Huo, B. J. Gorsline, G. C. Fu*, “Catalyst-controlled douly enantioconvergent coupling of racemic alkyl nucleophiles and electrophiles”, Science 2020, 367, 559-564. (featured in Science 2020, 367, 509-510highlighted in C&EN as one of sensational syntheses of 2020.)

  5.  H. Huo, K. Harms, E. Meggers*, “Catalytic, Enantioselective Addition of Alkyl Radicals to Alkenes via Visible-Light-Activated Photoredox Catalysis with a Chiral Rhodium Complex”, J. Am. Chem. Soc. 2016, 138, 6936-6939.

  6.  H. Huo, C. Wang, K. Harms, E. Meggers*, “Enantioselective, Catalytic Trichloromethylation through Visible-Light-Activated Photoredox Catalysis with a Chiral Iridium Complex”, J. Am. Chem. Soc. 2015, 137, 9551-9554.

  7.  H. Huo, X. Shen, C. Wang, L. Zhang, P. Röse, L.-A. Chen, K. Harms, M. Marsch, G. Hilt, E. Meggers*, “Asymmetric Photoredox Transition-Metal Catalysis Activated by Visible Light”, Nature 2014, 515, 100-103.

  8.  H. Huo, C. Fu, K. Harms, E. Meggers*, “Asymmetric Catalysis with Substitutionally Labile yet Stereochemically Stable Chiral-at-Metal Iridium(III) Complex”, J. Am. Chem. Soc. 2014, 136, 2990-2993.

 

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