讲座题目：Physical and Chemical Approaches for Enhancing Optical Biosensors
讲座人：Qiuming Yu，University of Washington, USA
讲座时间：2019 年 10 月31 日下午 16:00
讲座地点：卢嘉锡楼202
个人简介：
Qiuming Yu is a professor in Chemical Engineering at the University of Washington. She received her B.S. and M.S. in Chemistry from Nanjing University in China, her Ph.D. in Chemical Engineering from Cornell University, and did postdoctoral research in Micro-devices Laboratory at the NASA Jet Propulsion Laboratory / California Institute of Technology. Her research focuses on plasmonic nanostructures and inorganic, polymeric and hybrid semiconductor nanomaterials for chemical and biological sensors and optoelectronic devices.
讲座摘要：
Physical and Chemical Approaches for Enhancing Optical Biosensors
Qiuming Yu
Department of Chemical Engineering, University of Washington, Seattle, WA, USA
Optical biosensors based on surface resonance plasmon (SPR) and surface-enhanced Raman scattering (SERS) have emerged as a powerful analytical and sensing technique with broad applications, such as food safety, biomedicine, homeland security, and environmental monitoring, because of the label-free, real-time detection capability offered by SPR biosensors and molecular specificity and high sensitivity enabled by SERS. For the SPR biosensors, I will cover our recent effort in the development of dually functional interdigitated electrodes to sustain SPR and to increase bacterial mass transport through external application of dielectrophoresis for the detection of low concentration bacteria. For SERS biosensors, since electromagnetic enhancement dominates the SERS effect due to extremely strong local electric fields (i.e., hot spots) induced by localized surface plasmon resonance (LSPR), the development of plasmonic nanostructures as SERS-active substrates is one of the frontiers in this field. I will first talk about our effort on the development of SERS-active plasmonic nanostructures that can sensitive detect small and large analytes. As detection using SERS is typically carried out on bare metal surfaces, because of the near field effect, non-specific adsorption frequently occurs and significantly reduces detection performance. In this regard, I will talk about our effort on the development of stealth surface modification and hierarchical zwitterionic modification for SERS substrates to enable the sensitive and specific detection in protein solution and real-time drug monitoring from blood plasma, respectively.
