题目: Development and Application of Ambient Ionization Sources for Mass Spectrometry
讲座人: Prof. Dr. Renato Zenobi, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland
时间: 2019年11月8日（周五）10:30-11:30
地点: 卢嘉锡楼202报告厅
报告人简介：
Renato Zenobi is Professor of Analytical Chemistry at the Swiss Federal Institute of Technology (ETH) Zurich. Born in Zurich in 1961, he received a M.S. degree from the ETH Zurich in 1986, and a Ph.D. at Stanford University in the USA in 1990. After two postdoctoral appointments at the University of Pittsburgh and at the University of Michigan, Renato Zenobi returned to Switzerland in 1992 as a Werner Fellow at the EPFL, Lausanne, where he established his own research group. He became assistant professor at the ETH in 1995, and was promoted to full professor in 2000. Zenobi was a visiting professor at the Barnett Institute (Boston) in 2004/2005, and at the Institut Curie (Paris) in 2010.
Renato Zenobi has received many awards for his scientific work, including the Heinrich Emanuel Merck-Prize (1998), the Michael Widmer Award (2006), several honorary Professorships in China (Hunan University; East China Institute of Technology; Changchun University of Chinese Medicine; Chinese Academy of Sciences, Changchun), the Thomson Medal (International Mass Spectrometry Foundation, 2014), the 2014 RUSNANO prize, the Fresenius Award (2015, German Chemical Society/GDCh), and an ERG Advanced grant (2017). He is Associate Editor of Analytical Chemistry (American Chemical Society).
讲座摘要：
The first report of desorption electrospray ionization (DESI) by Cooks et al. in 2004 triggered immense interest in further exploration of alternative “ambient” approaches for generating ions directly from sample surfaces in open air. As a result, more than two dozen other ambient ionization techniques have since been developed. These new methods of producing ions have simplified the mass spectrometric analytical procedure, thus increasing throughput. Several of these new ambient ionization methods employ atmospheric plasmas, including direct atmospheric pressure photoionization (DAPPI), direct analysis in real time (DART), flowing atmospheric pressure afterglow (FAPA), plasma-assisted desorption ionization (PADI), desorption atmospheric pressure photoionization (DAPCI), low-temperature plasma (LTP) ionization, and dielectric barrier discharge ionization (DBDI). In this lecture, the recent development of ambient ionization mass spectrometers, as well as their applications and potential in clinical diagnosis and therapeutic monitoring will be discussed. The future development of MS systems with ambient ionization with perspectives on the challenges in technical development will be speculated.
