方柏山

个人简历：

博士（天津大学，2000）
访问学者（德国生物技术研究中心，2000-2001年）
        （德国斯图加特大学生化工程研究所，1991-1993年）
学士（浙江大学，1982.1）

研究兴趣：
合成生物学与生物分子机器；定向进化与生物催化；生物技术过程开发与优化；肠道菌群体外培养与功能开发

近期主要代表论著：

1. 1. You-SiFu, Kai-NanChen, Jun-NanZhang, Chuan-XingXiao, Li-NaFan, Bang-ZhouZhang, Jian-LinRen*, Bai-ShanFang*, Evaluation of the effects of four media on human intestinal microbiota culture in vitro, AMB EXPRESS9: 69(2019).

2. 2. Ai-Hui Zhang, Shi-Yang Huang, Xiao-Yan Zhuang,KeWang,Chuan-YiYao*, Bai-ShanFang*.A novel kinetic model to describe 1,3-propanediol production fermentation by Clostridium butyricumAiChE Journal 65: UNSP e16587

3. 3. Ai-Hui Zhang, Xiao-Yan Zhuang, Kai-Nan Chen, Shi-Yang Huang, Chao-Zhen Xu, Bai-Shan Fang*, Adaptive evolution of Clostridium butyricum and scale-up for high-concentration 1,3-propanediol production, AiChE Journal 65: 32-39 (2019).

4. 4. You-Si Fu, Jun-Nan Zhang, Kai-Nan Chen, Chuan-Xing Xiao, Li-Na Fan, Bang-Zhou Zhang, Jian-linRen*, Bai-Shan Fang*, An in vitro fermentation study on the effects of Dendrobiumofficinale polysaccharides on human intestinal microbiota from fecal microbiota transplantation donors, Journal of Functional Foods 53: 44-53(2019).

5. 5. Yong-Hui Zhang, Kai-Nan Chen, Jun-Nan Zhang, Hong Ren, Xin‐Yu Zhang, Jing‐Han Huang, Shi-Zhen Wang*, Fang Bai-Shan*, Preparation and evaluation of a polymer-metal-enzyme hybrid nanowire for the immobilization of multiple oxidoreductases, Journal of Chemical Technology and Biotechnology94: 795-803(2019).

6. 6. Wei Jiang, Ruo-Nan Yang, Peng Lin, Wen-Jing Hong*, Bai-Shan Fang*, Bioinspired genetic engineering of supramolecular assembled formate dehydrogenase with enhanced biocatalysis activities, Journal of Biotechnology292: 50-56(2019).

7. 7. Ai-HuiZhang, Hao-LinLiu, Shi-YangHuang, You-SiFu, Bai-ShanFang*, Metabolic profiles analysis of 1,3-propanediol production process by Clostridium butyricum through repeated batch fermentation coupled with activated carbon adsorption, Biotechnology and Bioengineering 115: 684-693 (2018).

8. 8. PengLin, Yong-HuiZhang, HongRen, Yi-XuanWang, Shi-ZhenWang*, Fang Bai-Shan*, Assembly of graphene oxide-formate dehydrogenase composites by nickel-coordination with enhanced stability and reusability, Engineering in Life Sciences 18, 326-333(2018).

9. 9. Yong-HuiZhang, Ya-LiWang, Shi-ZhenWang*, Bai-ShanFang*, Engineering bi-functional enzyme complex of formate dehydrogenase and leucine dehydrogenase by peptide linker mediated fusion for accelerating cofactor regeneration, Engineering in Life Sciences17: 989-996 (2017).

10. 10. WeiJiang, Shi-ZhenWang, Yuan-PengWang, Bai-ShanFang*, Key enzymes catalyzing glycerol to 1,3-propanediol, Biotechnology for Biofuels9(2016).

11. 11. Chun-JieZhu, Bai-ShanFang*, Shi-ZhenWang, Effects of culture conditions on the kinetic behavior of 1,3-propanediol fermentation by Clostridium butyricum with a kinetic model, Bioresourous Technology 212: 130-137 (2016).

12. 12. WeiJiang, Wen-JunLi, YanHong, Shi-ZhenWang, Bai-ShanFang*, Cloning, expression, mutagenesis library construction of glycerol dehydratase, and binding mode simulation of its reactivase with ligands. Applied Biochemistry and Biotechnology 178(4): 739-752 (2016).

13. 13. Ji-XueLu, Yong-HuiZhang, Dong-FangSun, WeiJiang, Shi-ZhenWang, Bai-ShanFang*, The development of leucine dehydrogenase and formate dehydrogenase bifunctional enzyme cascade improves the biosynthsis of l-tert-leucine, Applied Biochemistry and Biotechnology180(6): 1180-1195 (2016).

14. 14. WeiJiang, Bai-ShanFang*, Construction and evaluation of a novel bifunctional phenylalanine-formate dehydrogenase fusion protein for bienzyme system with cofactor regeneration, Journal of Industrial Microbiology & Biotechnology43(5): 577-584 (2016).

15. 15. WeiJiang, PengLin, Ruo-NanYang, Bai-ShanFang*, Identification of catalysis, substrate, and coenzyme binding sites and improvement catalytic efficiency of formate dehydrogenase from Candida boidinii, Applied Microbiology and Biotechnology 100(19): 8425-8437 (2016).