林泓域/Hongyu Lin
副教授、博士生导师
电话：86-592-2181963
办公室：卢嘉锡楼542室
电子邮箱：hylin007@xmu.edu.cn
课题组网页：https://jhgao.xmu.edu.cn/
个人简历：
学士（南京大学biwn必赢，2003-2007）
博士（美国Brandeis University化学系，2007-2012）
博士后（美国Cornell University化学与化学生物学系，2013-2015）
副教授（biwn必赢化学生物学系，2016-）
福建省化学生物学重点实验室和谱学分析与仪器教育部重点实验室固定成员。主持国家自然科学基金重大研究计划培育项目、面上项目、福建省自然科学基金杰出青年基金项目、厦门市青年创新基金项目等，参与编写全国高等学校教材《临床分子影像检测技术》，授权中国发明专利3项。
研究兴趣：
磁共振造影剂；19F磁共振探针；19F代谢标记；分子探针；肿瘤诊疗
近期主要代表论著：
# co-first authors, * corresponding authors
1. Luo, X.; Kang, B.; Chi, X.; Xiong, H.; Chen, D.; Fan, Y.; Li, L.; Chen, L.; Li, A.; Gao, J.; Lin, H.* 19F Barcoding Enables Multiplex Detection of Biomarkers Associated with Organ Injury and Cancer Angew. Chem. Int. Ed. 2022, 61, e202211189.
2. Yang, Z.#; Sun, C.#; Lin, Y.; Lin, H.; Gao, J.; Lin, H.* Sequence-Controlled Heterolayered Lanthanide-Complex Dendritic Architectures Constructed from Modular Ln-DOTA Derivatives. Cell Rep. Phys. Sci. 2022, 3, 100950.
3. Lin, H.; Tang, X.; Li, A.; Gao, J.* Activatable 19F MRI Nanoprobes for Visualization of Biological Targets in Living Subjects. Adv. Mater. 2021, 33, 2005657.
4. Chen, D.; Lin, Y.; Fan, Y.; Li, L.; Tan, C.; Wang, J.; Lin, H.*; Gao, J.* Glycan Metabolic Fluorine Labeling for In Vivo Visualization of Tumor Cells and In Situ Assessment of Glycosylation Variations. Angew. Chem. Int. Ed. 2023, 62, e202313753.
5. Chen, D.#; Guo, J.#; Li, A.; Sun, C.; Lin, H.; Lin, H.*; Yang, C.*; Wang, W.*; Gao, J.* Metabolic Fluorine Labeling and Hotspot Imaging of Dynamic Gut Microbiota in Mice. Sci. Adv. 2023, 9, eabg6808.
6. Fan, Y.; Chen, D.; Chen, L.; Liu, K.; Zheng, Y.; Li, L.; Li, J.; Lin, H.*; Gao, J.* Fluorinated Iron Metal–Organic Frameworks for Activatable 19F Magnetic Resonance Imaging and Synergistic Therapy of Tumors. Nano Lett. 2023, 23, DOI: 10.1021/acs.nanolett.3c04402.
7. Tang, X.#; Li, A.#; Zuo, C.; Liu, X.; Luo, X.; Chen, L.; Li, L.; Lin, H.*; Gao, J.* Water-Soluble Chemically Precise Fluorinated Molecular Clusters for Interference-Free Multiplex 19F MRI in Living Mice. ACS Nano 2023, 17, 5014.
8. Liu, K.#; Cai, Z.#; Chi, X.#; Kang, B.; Fu, S.; Luo, X.; Lin, Z.-W.; Ai, H.*; Gao, J.*; Lin, H.* Photoinduced Superhydrophilicity of Gd-Doped TiO2 Ellipsoidal Nanoparticles Boosts T1 Contrast Enhancement for Magnetic Resonance Imaging. Nano Lett. 2022, 22, 3219.
9. Liu, K.; Kang, B.; Luo, X.; Yang, Z.; Sun, C.; Li, A.; Fan, Y.; Chen, X.; Gao, J.*; Lin, H.* Redox-Activated Contrast-Enhanced T1-Weighted Imaging Visualizes Glutathione-Mediated Biotransformation Dynamics in the Liver. ACS Nano 2021, 15, 11831-11841.
10. Sun, C.#; Lin, H.#; Gong, X.; Yang, Z.; Mo, Y.; Chen, X.; Gao, J.* DOTA-Branched Organic Frameworks as Giant and Potent Metal Chelators. J. Am. Chem. Soc. 2020, 142, 198-206.
11. Luo, X.#; Gong, X.#; Su, L.#; Lin, H.#; Yang, Z.; Yan, X.; Gao, J.* Activatable Mitochondria-Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy. Angew. Chem. Int. Ed. 2021, 60, 1403-10.
12. Lin, H.-Y.; Haegele, J. A.; Disare, M. T.; Lin, Q.; Aye, Y.* A Generalizable Platform for Interrogating Target- And Signal-Specific Consequences of Electrophilic Modifications in Redox-Dependent Cell Signaling. J. Am. Chem. Soc. 2015, 137, 6232-44.
